An international team of researchers from Sweden, USA and Switzerland found that treatment of liver cells of rats with a substance called “sulforaphane” reduces the production of glucose. In a study that scientists published in the online edition of Science Translational Medicine, described the method of allocation of sulforaphane from vegetables and monitoring with the participation of volunteers.
Sulforaphane is an organic compound of plant origin. The precursor of sulforaphane glucoraphanin is in such vegetables as broccoli, cauliflower, kohlrabi, watercress, etc. Most rich glucoraphanin sprouts, broccoli and cauliflower. If the damage to the plants (for example, when chewed) plant enzyme myrosinase transformerait glucoraphanin into sulforaphane, which is an antibacterial agent and is involved in the system of plant protection from infection.
Recently diabetes type 2 diabetes is actively studied, since this disease is associated with the obesity epidemic that began in many developed countries, especially in the United States. Previous studies have shown that type 2 diabetes is a condition which interferes with the sensitivity of cells to insulin and their ability to absorb glucose. As a result, unclaimed carbohydrate accumulates in the blood, which leads to the development of numerous health problems.
For the treatment of diabetes mellitus type 2 currently used diet and ingestion of such drugs as Metformin. But some remedies for the treatment of diabetes — cause serious side effects, for example, they can damage the liver, so scientists continue to search for drugs. The authors of the new study managed to discover a connection that helps overcome symptoms of diabetes other way. To do this, scientists have created a “genetic signature” of the disease, based on 50 genes. Having processed these data, the researchers engaged in the search for chemical compounds related to expression of certain genes. And sulforaphane was the most effective of the currently known substances.
Then, the experimenters raised the cell culture of rats suffering from diabetes mellitus type 2, and treated these cells with sulforaphane, expecting that as a result, the production of glucose will decrease. Encouraged by the first results, they proposed a 12-week course of sulforaphane 97 volunteers with type 2 diabetes. A quick transition to human trials is made possible due to the fact that sulforaphane — a substance present in edible plants of the Cabbage family, like broccoli. It turned out that treatment with sulforaphane significantly reduces blood glucose level on an empty stomach.
The authors note that the results are preliminary, and to confirm the effectiveness of sulforaphane or diets with a high content of cruciferous plants, will require additional research. In addition, issledovatelei emphasize that the method used to detect the use of sulforaphane, applied to other diseases.