One of the most frequent and severe manifestations of diabetes is peripheral neuropathy. The reason for this pathological state is in violation of metabolic processes in nervous tissue. This inevitably leads to problems with the transmission of impulses along nerve fibers, and, depending on the body that the fiber innervates, manifest diverse pathological symptoms. Among the various forms of autonomic diabetic neuropathy as one of the most unpleasant for the patient it is necessary to highlight erectile dysfunction (ED), which can be treated cialis.
Erectile dysfunction is defined as difficulty achieving and/or maintain an erection necessary for sexual intercourse. According to various sources, ED to occur in 30-65% of men with diabetes. The condition is caused by dysfunction of the parasympathetic nervous system and is often one of the earliest manifestations of lesions of the autonomic nerves. In contrast to psychogenic impotence erectile dysfunction, organic nature with prolonged hyperglycemia is characterized by the absence of spontaneous night and morning erections and additionally almost always accompanied by other manifestations of lesions of peripheral nerves: distal polyneuropathy, dysfunction of the bladder and gastrointestinal tract. The development of ED is directly due to the long duration of diabetes. Erectile disorders in diabetes lead to a significant deterioration in the quality of life of men, are often the cause of depressive disorders.
Prolonged hyperglycemia occur microcirculation disorders in the genital organs, affects the autonomic nerve fibers of the penis, the smooth muscle cells. In addition, elderly patients with diabetes mellitus observed age-related decline of sex hormones, which introduces a further contribution to the maintenance of erectile dysfunction. Proven pathogenetic key role in the development of the above mentioned breaches of oxidative stress, the accumulation of free radicals and damage to nerves and vascular endothelium. This should be considered when selecting therapy for such patients. Especially for treatment of violations of potency, as and other forms of diabetes, it is necessary to compensate for the hyperglycemia. It is known that peripheral neuropathy is directly correlated not only with age but also with the duration of disease and glycosylated hemoglobin. And according to the degree of reduction of hyperglycemia it is possible to evaluate the effectiveness of drug therapy.
Essential drugs in violation of potency associated with diabetes, are inhibitors of phosphodiesterase; the α2-adrenergic receptors; tonic medicines. While reducing the level of testosterone is substitution therapy with hormones. But attempts to symptomatically treat erectile dysfunction, which developed as a result of diabetic neuropathy, doomed to failure. Reduced to restore virility will help careful correction of metabolism. Positive results as pathogenetic therapy along with other medication and maintain normal blood sugar level gives the use of drugs thioctic acid, in particular, Thioctacid® BV. The result of the inclusion of α-lipoic acid rapid release in the scheme of treatment is the restoration of lipid and carbohydrate metabolism in the cell, strengthening the antioxidant defense of the cells, removal of toxic products of disturbed metabolism, normalization of the functioning of nerve fibers and elimination developed erectile dysfunction.